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10.1073/pnas.1102561108 [DOI] [PMC free article] [PubMed] [Google Scholar] Judson M

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Through high-frequency ctDNA detection, clinicians can detect resistance trends (such as RRM2 copy number doubling) earlier than imaging, and guide the adjustment of treatment plans (such as switching to RRM2 inhibitor 3-AP or combined with METTL3 inhibitor) to avoid ineffective chemotherapy

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From this set of CSD-containing proteins, three different proteins were selected for detailed studyCD4, ERO1, and AKT1